Textbook Of Medical Physiology by Krishna A.P

Author:Krishna, A.P. [Krishna, A.P.]
Language: eng
Format: azw3
Publisher: Medtech Publisher
Published: 2019-02-17T16:00:00+00:00

Indirect actions of growth hormone

GH actions are mediated through formation of certain polypeptides called as insulin like growth factor or somatomedins. There are two prominent types of IGFs- IGFI somatomodin C and IGFII.

IGF-II is prominent during fetal life—IGF-I is prominent in post natal life. IGFs are mostly formed by liver in response to GH action. IGF plasma concentration is about 20–700 ng/ml.IGFs act like insulin . It can bind with insulin receptor. It promotes the growth.

Stress Dopamine High plasmaglucose

Sleep + High plasma FFA –

+ +– Hypothalamus –

GHRF GHF

+ Somatostatin

Anterior pituitary– –

GH +

Liver

IGF

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